How to Tell the Difference Between Skin Cancer and a Mole

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Identifying moles vs. skin cancer is not always easy. However, there are telltale signs that can help differentiate a benign (non-cancerous) skin lesion from potentially dangerous skin cancer.

Benign moles come in various shapes, sizes, and colors (e.g., pink moles, brown moles, flat moles, raised moles, etc.), but are usually round with smooth edges.

When checking for early signs of a potential melanoma it's helpful to use the ABCDE rule, which stands for:

  • Asymmetry: An irregular shape
  • Border: Ragged, notched, or blurred edges
  • Color: Variations in color within the mole
  • Diameter: Diameters over 6 millimeters
  • Evolving: Changes in size, shape, color, or appearance
ABCDE Rule: Moles vs Skin Cancer Melanoma

Illustration by Joules Garcia for Verywell Health

Symmetry

What Moles Look Like

This is an example of a normal mole. Note that it is almost perfectly round.

normal mole

A mole is a benign melanocytic tumor, meaning a non-cancerous skin lesion that develops from pigment-producing cells called melanocytes.

Also known as nevus (singular) and nevi (plural), moles are not usually present at birth but begin to appear during childhood and the teen years. They can either develop on the top layer of skin (epidermis) or just under the skin (dermis).

What Melanoma Looks Like

Here is an example of melanoma. Melanoma differs in that the lesions are usually asymmetrical (lopsided).

Melanoma is a type of skin cancer that also develops from pigment-producing melanocytes. The primary cause of melanoma is overexposure to ultraviolet (UV) radiation from the sun or tanning beds.

Melanoma is the most dangerous type of skin cancer, affecting more than 230,000 people globally and causing over 50,000 deaths each year. In the United States, males are about 1.5 times more likely to get melanoma than females.

This photo contains content that some people may find graphic or disturbing.

Asymetric melanoma on skin

Reproduced with permission from © DermNet and © Waikato District Health Boardwww.dermnetnz.org 2023.

Borders

What Moles Look Like

Normal moles generally have well-defined borders along with uniform color. They can either be raised or flat (as pictured).

Despite variations in size or color, the vast majority of moles have smooth borders that are clearly separate from the surrounding skin. The color of the mole will typically be even rather than mottled.

normal moles

What Melanoma Looks Like

This melanoma tumor has a border that is uneven, ragged, and notched. The color also appears to "bleed" around the edges.

An uneven, jagged border is one of the tell-tale signs of melanoma. By contrast, moles tend to have smoother, more even borders.

While about 20%-30% of melanomas develop in existing moles, 70%-80% arise on seemingly normal skin.

Melanoma with border irregularity

Reproduced with permission from © DermNet and © Waikato District Health Boardwww.dermnetnz.org 2023.

Color

Moles vary in color. Some may be pink or flesh-colored, while others may be tan or brown (as pictured). Some can be small and freckle-like, while others may look like a Cindy Crawford-style beauty mark.

Moles are generally characterized by one or two shades of color. If you identify more or spot certain concerning colors (e.g., red, white, blue, or black) melanoma may be a concern.

Moles can change in color without becoming cancerous. For example, moles on the face will often start as brown but get lighter or darker with age. Moles can also raise or flatten (though they typically remain the same size).

normal mole color

What Melanoma Looks Like

In addition to asymmetry, uneven coloration is a hallmark of melanomas. The same lesion can have a range of colors, from tan, orange, and brown all the way to red, black, and blue.

Another clue that a person has melanoma is the so-called "ugly duckling sign."

By and large, the moles on a person's body will all look the same. However, if you step back and look at them in their entirety, there may be some that stand out as being different, either in terms of color, size, or shape.

These "ugly ducklings" may be an early sign of melanoma.

Melanoma with color variation
Melanoma with color variation.

Reproduced with permission from © DermNet and © Waikato District Health Boardwww.dermnetnz.org 2023.

Diameter

What Moles Look Like

Some moles may be bigger than others, but most are around 1 to 2 millimeters in diameter. On occasion, a mole may be up to 5 millimeters in diameter (1/5 inch), but this is rare.

Most moles never cause any problems, but, ironically, a person who has more than 50 has a higher risk of developing melanoma. These moles, called acquired moles, appear on the skin after birth (unlike congenital moles you are born with).

Most people have between 10 and 40 acquired moles on their body. Having a higher number warrants an annual check-up to examine parts of the body you cannot readily see, like your back and back of your neck.

normal moles sizes

What Melanoma Looks Like

Any mole over 6 millimeters (1/4 inch) in diameter should be looked at. Melanomas can be tiny, but most are larger than the size of a pea or pencil eraser.

The one pictured here is significantly larger.

In addition to the diameter of a lesion, the thickness of a lesion is also a red flag. With melanoma, the thicker the tumor, the poorer the outcome (prognosis).

Melanoma that is less than 1 millimeter thick has a low risk of spreading to other parts of the body. Melanoma thicker than 4 millimeters not only have a high risk of spreading (metastasizing) but also a high risk of returning (recurring) after treatment.

lentigo maligna melanoma skin cancer on the cheek

Reproduced with permission from © DermNet dermnetnz.org 2023.

Evolution

What Moles Look Like

A mole really doesn't change if you have one. While some may get a bit darker as you age, they will usually remain the same color, size, and shape.

This includes dermal nevi (pictured) that match the skin color of the surrounding skin.

Any changes in the color, size, or shape of a mole should be investigated. This includes changes in texture, such as sudden flaking or scaliness.

dermal nevus

CC BY-NC-ND

What Melanoma Looks Like

Melanoma is characterized by change as cancer cells start to multiply and spread. Any change in the size, shape, color, or appearance of a mole is an immediate red flag that melanoma may be involved.

This includes changes like:

  • The spread of pigment from the edge of a mole into the surrounding skin
  • Redness or a new swelling beyond the border of the mole
  • Change in sensation, such as itching, tenderness, or pain
  • Change in the surface of a mole, including scaliness, oozing, or bleeding
  • The appearance of a new lump or bump

The challenge, of course, is recognizing the changes. Unless you do a regular self-examination, you may not even notice a mole has changed unless it is bleeding or has caused a skin ulcer. This is especially true if you have lots of moles.

The Skin Cancer Foundation is among the organizations that endorse once-yearly skin exams.

This photo contains content that some people may find graphic or disturbing.

Melanoma on the ear

Reproduced with permission from © DermNet and © Te Whatu Ora dermnetnz.org 2023.

Skin Cancer Healthcare Provider Discussion Guide

Get our printable guide for your next healthcare provider's appointment to help you ask the right questions.

Doctor Discussion Guide Man

Understanding Dysplastic Nevi

There are atypical moles, also called dysplastic nevi. These are often larger, oddly shaped, oddly textured, and multi-colored but are not considered cancerous.

Cells from a dysplastic nevus don’t look completely normal under a microscope and may display some features resembling early-stage melanoma. However, these cells don’t have the features that make them cancerous. Dysplastic nevi rarely become cancerous.

Nevertheless, compared to ordinary moles, they have a higher risk of becoming cancerous, so it is important to have an irregular or changing mole checked by a dermatologist.

Summary

Moles and melanoma can be hard to tell apart. Dermatologists use a system called the ABCDE rule as a guideline for identifying cancerous lesions. ABCDE stands for asymmetry, border, color, diameter, and evolving.

These signs can help spot skin cancer early when it is still highly treatable. In addition to doing regular self-exams at home, an annual, full-body checkup with a dermatologist is often recommended.

12 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Daniel Jensen J, Elewski BE. The ABCDEF rule: Combining the "ABCDE rule" and the "ugly duckling sign" in an effort to improve patient self-screening examinations. J Clin Aesthet Dermatol. 2015;8(2):15.

  2. McCourt C, Dolan O, Gormley G. Malignant melanoma: a pictorial review. Ulster Med J. 2014;83(2):103-10.

  3. Black S, Macdonald-McMillan B, Mallett X, Rynn C, Jackson G. The incidence and position of melanocytic nevi for the purposes of forensic image comparison. Int J Legal Med. 2014;128(3):535-43. doi:10.1007/s00414-013-0821-z

  4. American Academy of Dermatology Association. Skin Cancer - Incidence rates.

  5. UnityPoint Health. 3 Types of Skin Moles.

  6. The Skin Cancer Foundation. Melanoma Warning Signs.

  7. National Cancer Institute. Common Moles, Dysplastic Nevi, and Risk of Melanoma - What is a common mole?

  8. American Cancer Society. Melanoma Skin Cancer Stages.

  9. Centers for Disease Control and Prevention. What Are the Symptoms of Skin Cancer?

  10. Skin Cancer Foundation. Annual Exams: Five Easy Steps to Prepare Yourself.

  11. Sung WW, Chang CH. Nevi, dysplastic nevi, and melanoma: molecular and immune mechanisms involving the progressionTzu Chi Med J. 2021;34(1):1-7. doi:10.4103/tcmj.tcmj_158_20

  12. National Cancer Society. Can a dysplastic nevus turn into melanoma?

By Timothy DiChiara, PhD
Timothy J. DiChiara, PhD, is a former research scientist and published writer specializing in oncology.